LEP and Hyperglycemia: Our mediation model might also support that PRDM16 could mediate the association between maternal hyperglycemia at the third trimester of pregnancy and cord blood leptin levels (CpG2, β = 0.14, p = 0.004) (Fig. 3c), but the size of the direct effect (correlation between maternal hyperglycemia at the third trimester of pregnancy and cord blood leptin levels—c path) is too small (p > 0.05) to support conclusive results.