IL33 and gastric cancer: Sun et al. reported that IL-33 levels in the serum of gastric cancer patients were significantly elevated in comparison with that of healthy volunteers, and higher serum levels of IL-33 in gastric cancer patients were found to correlate with several poor prognostic factors like depth of invasion, distant metastasis, and advanced stage and serum immunoglobulin levels can be elevated by either stimulation of cells with IL-33 or binding of IL-33 to the ST2L in the process of some cancers [25].