After counting crude numbers of Fap+Yfp+ cells (Fig. 2e) and then correction for efficiency of Yfp expression among CD31+ cells in our murine model, we established that 32.5±8.5% of intimal plaque Fap+ cells were endothelial-derived after 8 weeks of HFD, while 45.5±23.3% of intimal Fap+ cells were endothelial-derived in mice with advanced atherosclerotic lesions after 30 weeks HFD (Fig. 2f). This evidence concerns the gene PECAM1 and Atherosclerotic lesion.