CLOCK and lymphoma: Consistent with our observation in U2OS cells, expression of both clock genes correlated inversely with MYC levels in human lymphoma (Pearson coefficient −0.61 and −0.37 for BMAL1 and CLOCK, respectively; n=102), whereas MYC-activated genes such as NCL and NCLN showed a positive correlation (Fig. 6a,b and Supplementary Fig. 6).