DSG2 and Arrhythmogenic right ventricular dysplasia: Historically, studies of DSG2 function have focused on its role in desmosomes, with important clinical implications for understanding the pathogenesis of cardiac disease with increasing reports of dominantly inherited frameshift, splice site, nonsense and missense mutations of DSG2 (mostly in the extracellular domain) in sudden death from ARVC as well as sudden unexplained death [60–62].