NFKB1 and hematologic disorder: Thus, while excessive activation of NF-κB has been shown to play a role in hematological malignancies [5], loss-of-function mutations in genes of the canonical and non-canonical NF-κB pathway have been associated with distinct types of primary immunodeficiency disorders including deficiencies of NEMO [6] or IKKβ [7] and BAFF receptor [8], CD40/CD40 ligand [9, 10], NIK [11], AID [12], or autosomal dominant mutations affecting NFκB2 [13, 14], respectively.