MAPT and Alzheimer disease: Based on numerous prior studies, the mechanisms of Aß-, Tau-, and αSyn-triggered neuronal injury in AD and PD, respectively, have many features in common, including aggregation, pathologic propagation [59], and overlapping cytotoxic profiles (e.g. synaptic changes [4, 56], mitochondrial dysfunction/oxidative stress [24, 61], and altered proteostasis [34]).