Recent conference reports described increased weight gain on high fat diet (HFD)-fed mouse with through-life expression of GLO-1 siRNA and mild Glo-1 deficiency, compared to wild-type controls [15], and decreased weight gain in Glo-1 overexpressing transgenic mice [16], suggesting a functional role of Glo-1 and dicarbonyl stress in obesity. The gene discussed is GLO1; the disease is Obesity.