With the broader adoption of next generation sequencing, mutations of RNF43 were subsequently identified in a variety of cancers including colorectal adenocarcinomas [38], endometrial carcinomas [38], mucinous ovarian carcinoma [39], pancreatic cancer [40,41], and gastric cancer [42] at frequencies ranging from 4.0% to 18.9% (Table 1). The gene discussed is RNF43; the disease is cancer.