SH2D3C and Rotavirus infection: In fact, it was recently reported that NSP3 has an additional mechanism to prevent the translation of cellular mRNAs: PABP is a shuttling protein that assists the transport of mRNAs from the nucleus to the cytoplasm, where they become accessible to the translation machinery; during rotavirus infection, PABP becomes accumulated in the nucleus of infected cells [22,34,35,36], and it was found that NSP3, and more precisely the eIF4G-binding domain of this protein, is important for the nuclear localization of PABP [35,36].