Since NSP3 dimers interact with eIF4G in the same region as PABP does, but with higher affinity [24], it has been proposed that during rotavirus infection NSP3 evicts PABP from eIF4G, impairing the translation of cellular mRNAs, while leading to the enhancement of translation of rotaviral mRNAs [26]. Here, SH2D3C is linked to Rotavirus infection.