The characterization of the three branches of UPR in rotavirus-infected cells showed that, during the infection, the mRNA of XBP1 is spliced by IRE1, ATF6 is relocalized to the cell nucleus, PERK and eIF2α are phosphorylated, and the transcription of GRP78 and CHOP mRNAs is induced, indicating that the UPR is activated in infected cells [54,55]. This evidence concerns the gene EIF2A and infection.