Similarly, high IGF-1 is associated with increased breast cancer risk in both premenopausal women (comparison of highest to lowest quintile, odds ratio (OR) = 1.2 (95% CI, 1.0–1.5)) and postmenopausal women (OR = 1.33 (95% CI, 1.1–1.6)) [49]. This evidence concerns the gene IGF1 and breast carcinoma.