When these 85 genes were ranked by average Z-score, the most common cancer hallmark to which these 85 genes mapped was sustained proliferation (Top 5 genes: DUOX1 (dual oxidase 1), SURF1 (surfeit 1), CYCS (cytochrome c (somatic)), GNPDA1 (glucosamine-6-phosphate deaminase 1), PHKA1 (phosphorylase kinase, α1)). The gene discussed is SURF1; the disease is cancer.