The concentrations of bone markers, like bone-specific alkaline phosphate, amino-terminally cross-linked telopeptides, tartrate-resistant acid phosphatase type 5b, osteopontin, OPG and RANKL, in patients with bone metastases also do not differ significantly from those of patients with RCC metastasis to other organs. The gene discussed is TNFSF11; the disease is renal cell carcinoma.