MET and non-small cell lung carcinoma: To investigate whether the c-Met pathway influences the trafficking of β1-integrin, Flow cytometry, biotin internalization assays and confocal imaging were used in the following cell models: ‘β1A cells' corresponding to β1-integrin null GD25 cells22 re-expressing β1-integrin23; NIH3T3 cells expressing c-Met mutant M1268T, the oncogenicity of which results from constitutive activation and endocytosis/trafficking6; and the human epithelial, breast MDA-MB-468 and non-small cell lung carcinoma A549 cell lines24, 25.