Several groups found that flagellin inhibited breast cancer through induction of caspase-1 activation-dependent pyroptosis, which was activated by the TLR5 and NLRC4/Naip5 signaling pathway.[81–83] Autophagy is another classic TLR-mediated PCD, and it has dual and complicated roles in cancer. The gene discussed is NLRC4; the disease is breast carcinoma.