The tumor suppressor p53, in response to stress signals or antitumor agents, induced transcriptional upregulation of individual TLR gene, therefore enhanced TLR downstream signaling in cancer cells (Fig. 2).[53,88] Potential tumor suppressor MARVELD1 (MARVEL domain-containing 1), as a candidate regulator of TLR signaling, inhibits proliferation of cancer cells through regulating the expression of p53 and p16.[89–93]. Here, MARVELD1 is linked to cancer.