HP-NAP is able to enhance the induction of the T helper 1 (TH1) cell differentiation and reduce vascularization of cancer through induction of IFN-γ.[49] Lin et al found that TLR2 signaling in carcinogen diethylnitrosamine (DEN)-injured liver tissue induced intracellular senescence and activated autophagy to eliminate ROS accumulation and DNA damage, therefore, attenuated the development and progression of HCC. This evidence concerns the gene IFNG and hepatocellular carcinoma.