Results from animal and cellular studies indicated that the underlying mechanism of prostate cancer is related to the overexpression of cyclooxygenase-2 (COX-2).[12–14] Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) can inhibit the production of COX-2 and can potentially reduce prostate carcinogenesis.[15,16]. The gene discussed is PTGS2; the disease is Familial prostate cancer.