Thus, all the independent predictors resulting from the three separate multivariate models (clinical, laboratory, and histopathological) were subsequently included in a final multivariate model with SGE, lymphadenopathy, Raynaud phenomenon, anti-Ro/SSA or/and anti-La/SSB positivity, RF positivity, monoclonal gammopathy, and C4 hypocomplementemia being identified as independent predictors for NHL development: (OR [95%]: 4.3 [2.0–9.1], 4.2 [1.8–9.9], 2.3 [1.0–5.2], 3.8 [1.1–13.4], 3.7 [1.4–10.0], 3.2 [1.0–9.8], 3.0 [1.3–6.8]) (Table 5). The gene discussed is CALR; the disease is monoclonal gammopathy.