In a last step multivariate model, taken into consideration all the previously identified predictors, only SGE, lymphadenopathy, Raynaud phenomenon, anti-Ro/SSA or/and anti-La/SSB as well as RF positivity, monoclonal gammopathy, and C4 hypocomplementemia were determined as independent adverse predictors for NHL development. Here, SSB is linked to Lymphadenopathy.