Risk = EXP[SGE∗(1.456) + Raynaud phenomenon∗(0.831) + lymphadenopathy∗(1.445) + monoclonal gammopathy∗(1.158) + RF positivity∗(1.305) + C4 hypocomplementemia∗(1.088) + anti-Ro/SSA or/and La/SSB positivity∗(1.328)]/{1 + EXP [SGE∗(1.456) + Raynaud phenomenon∗(0.831) + lymphadenopathy∗(1.445) + monoclonal gammopathy∗(1.158) + RF positivity∗(1.305) + C4 hypocomplementemia∗(1.088) + anti-Ro/SSA or/and La/SSB positivity∗(1.328)]}. The gene discussed is CALR; the disease is monoclonal gammopathy.