Two congenital disorders are known to be associated with mutations in LBR: Pelger-Huët anomaly and Greenberg skeletal dysplasia (Oosterwijk et al., 2003; Shultz et al., 2003; Wassif et al., 2007; Waterham et al., 2003) (see Table 1). This evidence concerns the gene LBR and Pelger-Huet anomaly.