JPH2 deficiency resulted in hypertrophied and failing myocardium,27, 28, 29, 30 while Jph3 mutation caused Huntington's disease-like-2.31, 32 Notably, strategies to maintain JPH2 level can prevent the progression from hypertrophy to heart failure,33 which highlights the potential therapeutic prospect of JPHs in beta cells in preventing the progress of type 2 diabetes. Here, JPH3 is linked to type 2 diabetes mellitus.