PD151746 significantly increased the number of BrdU+/DCX+ (Figures 5a and b) and BrdU+/β3-tubulin+ cells (Figures 5c and d) in the ischemic striatum compared with the DMSO-treated control group at 35 d.p.i. The SNAP-25 (Figures 5e and f) and Synaptophysin levels (Figures 5g and h) in the IBZ were also significantly increased by the treatment with PD151746, indicating a dominant-negative effect of calpain 1 on neurogenesis and synaptogenesis during stroke recovery. The gene discussed is CAPN1; the disease is stroke disorder.