Our data showed for the first time that the delayed elevation of IL-17 A improved brain tissue repair and spontaneous recovery after stroke, as demonstrated by our data that blocking IL-17 A with IL-17 A neutralizing antibody or IL-17 A deficiency markedly inhibited ischemia-induced spontaneous recovery through reducing SVZ NPCs survival, migration of newly born neuroblasts into the ischemic striatum, neuronal differentiation and subsequent synaptogenesis. Here, IL17A is linked to stroke disorder.