AKT1 and stroke disorder: Furthermore, our results showed that p38 MAPK also have important role in IL-17 A-mediated neurogenesis after screening for PI3K/Akt and MAPK signaling pathways, which are major signaling pathways implicated in the proliferation and differentiation of NPCs.20, 21, 22, 23, 24 These data indicate that both p38 MAPK and calpain 1 are the downstream signal molecules for IL-17 A and have important roles in IL-17 A-mediated neurogenesis during stroke recovery.