The data support that ER stress activation, through PERK signalling, contributes to PD-associated neurodegenerative phenotypes in pink1 and parkin mutants, consistent with data in other models of neurodegeneration including prion disease3, 5 or tauopathy mice4 and a Drosophila model of Amyotrophic Lateral Sclerosis.22 Further, they support pharmacological inhibition of PERK signalling as neuroprotective. The gene discussed is PRKN; the disease is amyotrophic lateral sclerosis.