Among these, we observed a strong upregulation of TGFβ2, shown to induce cell death in Hep3B cells with low endogenous TGFβ levels.42 In addition, DKK3, which acts as a Wnt-antagonist and tumor suppressor, and the CDKN2B (coding for p15INK4B protein), which acts as a negative regulator of cell cycle progression,43, 44 were found to be upregulated in Hep3B cells upon NUPR1 suppression. The gene discussed is DKK3; the disease is neoplasm.