Several reports have indicated that sorafenib may induce cell death signaling pathways via endoplasmic reticulum (ER) stress activation.8, 9, 10 Our recent studies analyzing the molecular mechanisms of sorafenib treatment in human HCC cells identified several genes involved in ER stress response modulated by sorafenib.11 In particular, the stress-inducible gene nuclear protein-1 (NUPR1, also known as p8/Com-1) was upregulated after sorafenib treatment and its expression was found to be additionally potentiated on treatment with the anti-inflammatory drug celecoxib.11, 12. Here, NUPR1 is linked to hepatocellular carcinoma.