Several studies have shown that sorafenib blocks tumor cell proliferation and induces cell death through mitogen-extracellular activated protein kinase kinase (MEK)/ERK-dependent and -independent mechanisms.2, 3, 4, 5, 6, 7 In particular, ER stress has been demonstrated to be part of the MEK/ERK-independent program of cell death induced by this drug.8, 9, 10. Here, MAP2K7 is linked to neoplasm.