IER3 and hepatocellular carcinoma: We have shown that NUPR1 gene knockdown in HCC cells produces a significant downregulation of the pro-survival genes RELB and IER3. Specific siRNA was therefore used for RELB and IER3 silencing in Hep3B cells (Figure 5d and Supplementary Figure S2D), which led to a significant decrease in cell viability in basal conditions (Figure 5e and Supplementary Figure S2E, no treatment), and also significantly diminished clonogenic capacity (Figure 5f) and significantly increased cell sensitivity to sorafenib treatment (Figure 5e and Supplementary Figure S2E).