In the cross-sectional analysis (n = 498), we found no association between positivity for IgG aCL (OR: 1.23 [95% CI: 0.79–1.91]), IgM aCL (OR: 0.77 [95% CI: 0.37–1.60]), IgG anti-β2-GPI (OR: 1.31 [95% CI: 0.85–2.02]), or IgM anti-β2-GPI (OR: 0.80 [95% CI: 0.40–1.62]) at the time of enrolment and current or previous LN. Here, CD40LG is linked to lobular neoplasia.