Ofatumumab treatment was efficacious across distinct RA patient populations, i.e., patients with an inadequate response to DMARDs (study OFA111752), biologic-naïve patients with an inadequate response to MTX (study OFA110635), and patients refractory to TNF antagonists (study OFA110634), and was able to induce low disease activity and disease remission (based on DAS28-ESR), as also observed previously with repeated rituximab treatment [29, 30]. This evidence concerns the gene TNF and rheumatoid arthritis.