CHRNA4 and autosomal dominant nocturnal frontal lobe epilepsy: Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a familial partial epilepsy linked to mutations in the α2, α4, and β2 nicotinic acetylcholine (ACh) receptor (nAChR) subunits [1, 2], and the Na+-gated K+ channel, KCNT1 [3, 4].