LOX seems to be important in a later tumor stage in the transition to metastatic tumors by stiffening the extracellular matrix, reorganization of the cytoskeleton, increasing cell motility [73,74], inducing EMT [75,76], hypoxia-induced migration [32,77] and angiogenesis [78], as well as by setting up pre-metastatic niches [32,79]. This evidence concerns the gene LOX and metastatic neoplasm.