TP53 and breast cancer: As an example, Fig 3B and S6 Fig show a simplified subnetwork revealing the indirect relationships of a region harboring an NCV to genes associated with cancer, including the well-known tumor repressor TP53 and multiple breast cancer-associated genes, such as EIF4A [39], EIF5A [40,41], AURKB [42] and CLDN7 [43].