RAR signaling pathways have been linked to synaptic plasticity, dopamine regulation, and learning and memory deficits.40,41 Some of these novel interactors such as PTEN, PRKAR1B in this pathway are shown to be associated with neurodegenerative and neuropsychiatric disorders such as autism.42,43 Therefore, the interactors of RAR activation pathway may have a potential role in neuronal function such as neurotransmission. This evidence concerns the gene PTEN and autism.