For example, we discovered a PPI between OASL and DDX58, which on validation showed that an increased expression of OASL could boost innate immunity to combat influenza by activating the RIG-I pathway.22 Also, the interactome of the genes associated with congenital heart disease showed that the disease morphogenesis has a close connection with the structure and function of cilia.23 Here, we describe the HiPPIP model and its application to SZ genes to construct the SZ interactome. The gene discussed is RIGI; the disease is influenza.