PROS1 and schizophrenia: However, it is known that Slc39a12 has roles in controlling cyclicAMP-response-element-binding protein phosphorylation and activity, neurite outgrowth as well as microtubule polymerization and stability.13 It would be predicted that changes in these processes in human cortex would have profound effects on functionality and such effects could contribute to the pathophysiology of schizophrenia.