Consistent with the existing inverse correlation between the level of these viruses and the immunocompetence of an individual, Canuti et al hypothesized the presence of a higher immune activity during pregnancy in mothers whose offspring later develop a psychotic disorder as compared to controls.28 In addition to this, CMV is known for modulating MHC class I antigen presentation pathways29 and variations in the MHC region on chromosome 6p21.3–22.1 are highly associated schizophrenia.3 The gene discussed is HLA-C; the disease is schizophrenia.