The extracellular loops of PLP1 include four cysteine residues connected through intramolecular disulfide bonds that are crucial for protein folding, dimerization, and cellular trafficking.95 One study showed that reduction of PLP1 levels greatly reduced conduction velocity of myelinated axons in mice.96 Moreover, these mice displayed anxiety-like behaviors, reduced pre-pulse inhibition, spatial learning deficits, and working memory deficits, as found in SCZ. The gene discussed is PLP1; the disease is Anxiety.