Figure 1 and Supplementary Table 2 shows the association between CDR and COGS SNPs. Separate analysis of CDR in diagnostic groups, showed that rs5326 had the strongest association in controls (β=0.71; P=9.78×10−5) and cases with AD (β=0.86; P=2.81×10−4), while ranked third in cases with schizophrenia (β=0.61; P=8.05×10−4). The rs5326 is positioned in the promoter region of dopamine receptor D1 (DRD1). Here, DRD1 is linked to Alzheimer disease.