Serum NT-proBNP levels decreased by 77.3 pg/mL at 2 L of drainage (prealbumin administration) in those with cirrhosis compared to an increase of 10.47 pg/mL in the patients with malignancy (P = 0.05, 95% CI: −173.7–−1.7). Here, NPPB is linked to Cirrhosis.