Therefore, we suggest that (i) targeting DCLK1+ cells with a novel therapeutic approach using an innovative taxane antibody-drug conjugated (ADC) and (ii) inhibiting DCLK1 expression using novel DCLK1 inhibitors have the potential to reduce the process of cancer initiation, progression, and metastasis by regulating EMT and CSCs death, which will improve patients’ quality of life. This evidence concerns the gene DCLK1 and cancer.