What is more surprising, given the non-overlapping clinical phenotypes of NEK8-associated ciliopathies and ATR-associated Seckel syndrome patients, is that cells expressing a ciliopathy-associated kinase mutant NEK8 had an increase in DNA damage and cell cycle defects, and that the kidneys of NEK8 mutant mice accumulated DNA damage [106]. The gene discussed is NEK8; the disease is Seckel syndrome.