However, the role of HFE gene mutations on developing iron overload was previously studied in 41 beta-thalassaemia carriers in Egypt and it was found to be more common among beta-thalassaemia carriers compared with normal controls (H63D, S65C, and C282Y allele frequencies were 30.5%, 13.4% and 7.3% respectively in beta-thalassaemia carriers and 10.0%, 2.5% and 0.0% respectively in the control group). The gene discussed is HFE; the disease is Tangier disease.