In dominant models, it was found that RRM1 *151A>T had more than eightfold increased risk associated with the polymorphisms in patients with SCLC, with an adjusted OR of 8.54 (95% CI, 1.02–71.3; P = 0.48) for the A/A+A/T genotype as compared with the T/T genotype. The gene discussed is RRM1; the disease is small cell lung carcinoma.