Furthermore, several ALS/FTD genes, such as charged multivesicular body protein‐2B (CHMP2B), valosin‐containing protein (VCP), ubiquilin 2, p62 (sequestosome 1), optineurin, and TANK‐binding kinase (TBK1), are directly linked to autophagy. This evidence concerns the gene CHMP2B and amyotrophic lateral sclerosis.