Common indices of disease severity for TB consisted of symptom intensity (fever, hemoptysis), cavities in the chest radiograph, smear acid-fast and culture of MTB, hemoglobin concentration, lymphocyte count, erythrocyte sedimentation rate, and C-reactive protein (CRP) level, which was regarded as a regular inflammatory marker for host defense and innate immunity23. The gene discussed is CRP; the disease is tuberculosis.