Deregulated expression via mutations, gene rearrangements, or amplification of CCND1 has been reported in various cancer types.2–4 Also alterations of other proteins involved in the cyclin D1-CDK4/6-Rb axis (e.g., p16, retinoblastoma (Rb) protein, and p21) may lead to uncontrolled progression through the cell cycle.5,6 Even though the exact working mechanism of the SyS translocation is still unknown, it has been shown that the SS18-SSX fusion gene is associated with cyclin D1 expression in SyS cells. The gene discussed is RB1; the disease is cancer.