Indeed, this “cellular dedifferentiation” pathway is constitutively active in a SYT-SSX2 transgenic mouse model, with corresponding cyclin D1 expression, and inhibition of Wnt signaling through functional knock-out of the β-catenin gene reduced tumor formation.12,13 In line with this, blocking β-catenin with small molecule inhibitors in SyS cell lines resulted in cyclin D1 downregulation.14 Moreover, cyclin D1 activity could also be regulated by the PI3K/Akt-pathway. Here, CCND1 is linked to neoplasm.