As observed, ST2−/− mice had higher levels of TNF-α and IFN-γ transcripts locally (at the CNS) when analyzed 9 days post-infection (when disease symptoms are evident on ST2−/− mice); systemically (serum cytokines), the production of these cytokines were also increased, when compared to WT mice (Fig. 4g, h). The gene discussed is IFNG; the disease is infection.