EIF2AK2 and myeloid sarcoma: Quantitative evidence of neuronal dysmorphia was supported by the presence of C3b+ neurons expressing hypo-phosphorylated neurofilaments (Smi34+), neuronal nuclei expressing the pro-apoptotic kinase and neuronal stress/damage marker protein kinase R (pPKR) [29]—that were more numerous in MS GM in comparison to control GM (Fig. 5g, g′), and the presence of C3b+/cleaved caspase3+ or C3b+/TUNEL reaction+ cortical neurons (Fig. 5h, i).