Therefore, we were intrigued to see that cells and tumors lacking TCF7L1 had increased expression of EPHB3, a CTNNB1 target gene which has been shown to suppress tumor growth in mouse models of colorectal cancer19, reduce growth of cultured colorectal cancer cells20, and is enriched in lower grade areas of tumors36. This evidence concerns the gene TCF7L1 and colorectal cancer.