In addition, Jagle et al. 38 showed that this region is also occupied by markers of active enhancers (H3K27ac and p300), and their findings that EPHB3 is activated in early stage tumors but silenced in advanced tumors (corroborating work done by Battle et al.)is consistent with EPHB3 being both a target of Wnt signaling and a tumor suppressor. This evidence concerns the gene EP300 and neoplasm.