We also found enrichment of APEX1 neighbors for “PI3K-Akt signaling pathway” (KEGG pathway, P = 5.01e-04) and “regulation of gene expression by hypoxia-inducible factor” (Reactome pathway, P = 5.49e-05), both of which are well known cancer therapeutic target signaling pathways [46, 47]. The gene discussed is AKT1; the disease is cancer.