SHH and chronic kidney disease: For instance, besides Shh signaling pathway, TGF-β1, Wnt/β-catenin and Notch pathways are well recognized to play crucial roles in the evolution of renal fibrosis in CKD (Bielesz et al., 2010; He and Dai, 2015; He et al., 2009; Tan et al., 2014; Zhou et al., 2016).