In the past several years, the role and mechanisms of TGF-β, RAS and Wnt/β-catenin signaling in the pathogenesis of CKD have been well documented (Meng et al., 2015; Sweetwyne et al., 2014; Tan et al., 2014; Zhou et al., 2015). This evidence concerns the gene TGFB1 and chronic kidney disease.