Indeed, marked induction of Shh protein is observed in the fibrotic kidneys in all commonly used CKD models, including folic acid (FA), unilateral ureteral obstruction (UUO), ischemia reperfusion injury (IRI), adriamycin (ADR) and 5/6 nephrectomy, although it is barely detectable in normal kidneys (Ding et al., 2012; Fabian et al., 2012; Rauhauser et al., 2015; Zhou et al., 2014). The gene discussed is SHH; the disease is chronic kidney disease.