SHH and renal fibrosis: From a cell biological standpoint, the intricate process of renal fibrosis has been linked, more or less, to an inappropriate activation of some key signaling pathways, such as transforming growth factor-β (TGF-β), renin-angiotensin system (RAS), Wnt/β-catenin, and sonic hedgehog (Shh) (He and Dai, 2015; Meng et al., 2015; Santos et al., 2012; Sweetwyne et al., 2014; Tan et al., 2014).