CD4 and systemic lupus erythematosus: Similarly, the numbers of TNF-α+γ9+δT cells, TNF-α+CD4-CD8- γ9+δT cells and IL17+CD4-CD8- γ9+δT cells were significantly lower in SLE patients (0 week, prior to treatment) compared to healthy controls (Fig 3B, 3D and 3E).