Here, we provide evidence that the size of TNF-α+γδT cells, TNF-α+γ9+δT cells and IL17+CD4-CD8-γδT cells compartments may be very critical in exploring the incidence and progression of SLE and provide the necessary leads suggesting the need for further investigations exploring how these cells contribute to the induction of the disease. The gene discussed is CD4; the disease is systemic lupus erythematosus.