CDH1 and gastric cancer: Interestingly, NKX6.3 induced E-cadherin and γ-catenin expression with a concomitant decline in mesenchymal marker expression, including N-cadherin, Snail, Slug, and Vimentin, suggesting that NKX6.3 is able to inhibit EMT of gastric cancer cells, not only by inducing epithelial differentiation, but also by suppressing mesenchymal phenotype (Fig. 2).