Interestingly, NKX6.3 induced E-cadherin and γ-catenin expression with a concomitant decline in mesenchymal marker expression, including N-cadherin, Snail, Slug, and Vimentin, suggesting that NKX6.3 is able to inhibit EMT of gastric cancer cells, not only by inducing epithelial differentiation, but also by suppressing mesenchymal phenotype (Fig. 2). The gene discussed is NKX6-3; the disease is gastric cancer.