Furthermore, we found that NKX6.3 functions as a negative transcriptional regulator of RhoA, Cdc42, Rac1, Rac2, Skp2 and c-Myc genes and completely inhibits c-Myc-p300/CBP-Skp2-Miz1 and Max complex formation, thereby preventing gastric cancer cell migration and invasion (Fig. 6). This evidence concerns the gene SKP2 and gastric cancer.