The clone present in R1 and R6 acquired three focal losses late in its evolution that encompass known cancer genes such as VHL, a tumor suppressor gene commonly mutated in clear cell renal cell carcinoma (ccRCC) (Gnarra et al., 1994), and SIX1, a gene that was recently reported to be recurrently mutated in WT (Wegert et al., 2015, Walz et al., 2015) (3p25.3 − and 14q22.2–23.3 −, respectively). Here, SIX1 is linked to clear cell renal carcinoma.