H19 and Beckwith-Wiedemann syndrome: This finding is in keeping with previous reports of mosaic hypermethylation of the H19 DMR in a significant proportion of normal cells in cases of WT with this abnormality, even in the absence of other features of Beckwith-Wiedemann syndrome (Moulton et al., 1994, Okamoto et al., 1997, Scott et al., 2008b).