LGALS1 and cancer: Consistent with the reported ability of several CADs to induce lysosomal membrane permeabilization in other cancer cells (Petersen et al., 2013, Ostenfeld et al., 2008, Ellegaard et al., 2013, Sukhai et al., 2013), the cytotoxic CAD antihistamines induced lysosomal LGALS1 (galectin-1) puncta formation, a hallmark of lysosomal leakage (Aits et al., 2015), in A549, NCI-H1299 and NCI-H661 cells at concentrations around their LC50 values (Fig. 1e; Supplemental Fig. S1c; data not shown).