However, the polyfunctionality of CD8+ T cells ex vivo-stimulated with VNHRFTLV peptide on day 22 post-infection was not enhanced in DT-treated DEREG mice (Fig 8f), even though these mice were able to control T. cruzi infection better than their WT littermates, as measured by parasitemia in blood (Fig 8g). The gene discussed is CD8A; the disease is infection.