TACC1 and breast cancer: Furthermore, Aurora-C was found to co-localize with a breast cancer susceptibility gene, TACC1 (transforming, acidic coiled-coil containing protein 1) in the midbody of HeLa cells during cytokinesis and phosphorylate Serine 228 of TACC1 [18], indicating a possible TACC1 mediated role in the cellular transformation process.